hrp0095p2-255 | Sex Differentiation, Gonads and Gynaecology, and Sex Endocrinology | ESPE2022

Expression of Adam and Adamts Proteases Following Currative GnRHa Treatment for Cryptorchidism

Hadziselimovic Faruk , Verkauskas Gilvidas , Vincel Beata , Stadler Michael

Aim of the Study: ADAM/ADAMTS family members encode extracellular, multidomain proteolytic enzymes. Mutant Adamts16 mice display cryptorchidism and sterility. We hypothesize that gonadotropin-regulated ADAM/ADAMTS genes are involved in testicular development during mini-puberty.Patients and Methods: Testicular biopsies for histological and RNA-Sequencing analysis from bilateral cryptorchid boys were analyzed. RNA samples...